BazEkon - Biblioteka Główna Uniwersytetu Ekonomicznego w Krakowie

BazEkon home page

Meny główne

Turek Monika, Łodyga-Chruścińska Elżbieta
Zastosowanie w medycynie pochodnych indolu i jego kompleksów z biometalami
Application in Medicine of Indol the Derivatives and its Complexes with Biometals
Zeszyty Naukowe. Chemia Spożywcza i Biotechnologia / Politechnika Łódzka, 2008, nr 72 (nr 1029), s. 73-88, rys., bibliogr. 47 poz.
Słowa kluczowe
Towaroznawstwo, Towaroznawstwo żywności, Chemia, Chemia spożywcza, Przemysł farmaceutyczny, Medycyna
Commodity science, Food commodities, Chemistry, Food chemistry, Pharmaceutical industry, Medicine
summ., streszcz.
W oparciu o dane literaturowe przedstawiono charakterystykę i właściwości związków zawierających pierścień indolu. Pochodne związki indolu występują szeroko w przyrodzie w tkankach wielu roślin i zwierząt. Wykazują właściwości, które pozwalają na wykorzystanie ich w przemyśle farmaceutycznym. Dodatkowo mają zdolność kompleksowania biometali, dzięki czemu zyskują nowe właściwości lecznicze. W pracy dokonano przeglądu analogów oraz związków kompleksowych indoli, które już mają lub będą miały w przyszłości zastosowanie w medycynie i farmacji. (oryg. streszcz.)

Properties and applications of compounds containing indol rings have been reported. The indol derivatives have a broad occurrence in nature, in tissues of many plants and animals. Their properties make them applicable in pharmaceutical industry. Additionally they have a complexing ability towards biometals, therefore their new potential medicinal capabilities are still under investigation. Our paper is a literature review of indol derivatives and complexes which already have or may have in the future an usage in medicine and pharmacy. (original abstract)
Dostępne w
Biblioteka Główna Uniwersytetu Ekonomicznego w Krakowie
Biblioteka Główna Uniwersytetu Ekonomicznego w Poznaniu
  1. Crouch I. J, Smith M. T., Vanstaden J., Lewis M. J., Hoad G. V.: Identification of auxins in a commercial seaweed concentrate, J. Plant Physiol., 139,590-594, (1992).
  2. Moran P. M., Moser P. C.: MDL 73,147EF a 5-HT3 antagonist facilitates latent inhibition in the rat, Pharmacol. Biochem. Behav., 42, 519, (1992).
  3. Chauhan S. M. S., Mohapatra P. P., Kalra B., Kohli T. S., Satapathy S.: Biomimetic oxidation of indole-3-acetic acid and related substrates with hydrogen peroxide catalysed by 5, 10, 15, 20-tetrakis 2prime; 6prime; -dichloro- 3prime; -sulfonatophenyl) porphyrinatoiron(III) hydrate in aqueous solution and AOT reverse micelles, J. Mol. Catal. A: Chem., 113,239, (1996).
  4. Morzyk-Ociepa B., Michalska D., Pietraszko A.: Structures and vibrational spectra of indole carboxylic acids. Part I. Indole-2-carboxylic acid, J. Mol. Struct., 688, 87, (2004).
  5. Morzyk-Ociepa B., Michalska D., Pietraszko A.: Structures and vibrational spectra of indolecarboxylic acids. Part II. 5-Methoxyindole-2-carboxylic acid, J. Mol. Struct., 688, 79, (2004).
  6. Pradhan C., Pattnaik S., Dwari M., Patnaik S. N., Chand P. K.: Efficient plant regeneration from cell suspension-derived callus of East Indian rosewood (Dalbergia latifolia Roxb.), Plant Cell Rep., 18, 138, (1998).
  7. Okabe N., Adachi Y.: 1H-Indole-3-propionic Acid, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 54, 386, (1998).
  8. Pattnaik S. K., Sahoo Y., Chand P. K.: Micropropagation of a fruit tree, Morus australis Poir. syn. M. acidosa Griff, Plant Cell Rep., 15,841, (1996).
  9. Pradhan C., Kar S., Patnaik S. N., Chand P. K.: Propagation of Da1bergia sissoo Roxb. through in vitro shoot pro1iferation from cotyledonary nodes, Plant Cell Rep., 18, 122, (1998).
  10. Young-Kwan L., Cheon-Cyu C.:, Expedient synthesis of indoles from N-boc antyhydrozines, Tetrahedron Lett., 45,1857-1849, (2004).
  11. Kydyakova T. I., Sarycheva N. Yu., Kamensky A. A.: Study of the behavior of white rats with destroyed olfactory epithelium, Human and Animal Physio1ogy Department, Faculty of Bio1ogy, 45, 254, (1995).
  12. Takani M., Masuda H., Yamauchi O.: Palladium(II) complex formation by indole-3-acetate. Mixed ligand comp1exes invo1ving a unique spiro-ring formed by cyclopalladation, Inorg. Chim. Acta, 235, 367, (1995).
  13. Cheetham R. D., Mikloiche C., Glubiak M., Weathers P.: Micropropagation of a reca1citrant ma1e asparagus clone (MD 22-8), Plant Cell Tissue and Organ Culture, 31, 15, (1992).
  14. Blume H.H., Schug B.S.: The biopharmacetics classification system (BCS): Class III drugs - better candidates for BA/BE waiver?, Eur. J. Pharm. Sci., 9, 117-121, (1999).
  15. Morgan Y. R., Turner P., Kennedy B. J., Hambley T. W.: Preparation and characterization of dinuclear copper-indomethacin anti-inflammatory drugs, Inorg. Chim. Acta, 324, 150, (2001).
  16. Dejaco Ch., Duftner Ch., Schirmer M.: Lack of influence of body mass index on eficacy and tolerance of acemetacin in short-term treatment of musculoske1etal diseases, Rheumatol Int. 27, 351-355, (2007).
  17. Lione A.; Scialli A.R.: The deve1opmental toxicity of indomethacin and sulindac, Reprod. Toxicol., 9, 7-20, (1995).
  18. Bellamy N.: Etodolac in the management of pain: A clinical review of a mu1tipurpose analgesic, Inflammopharmaco1ogy, 5, 139-152, (1997).
  19. Arnao M.B., Sanchezbravo J., Acosta M.: Indole-3-carbinol as a scavenger of free radicals, Biochem. Mol. Biol. Int., 39, 1125, (1996).
  20. Podsędek A.: Naturai antioxidants and antioxidant capacity of Brassica vegetables, L WT - Food Sci. Technol. 40, 1-11, (2007).
  21. Dashwood R, H.: Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?, Chem. Biol. Interact., 110, 1-5, (1998).
  22. Michnovicz J. J.: A1tered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol, Nutr. Cancer, 16,59-66, (1991).
  23. Michnovicz J. J.: Changes in 1eve1s of urinary estrogen metabo1ites after oral indole-3-carbinol treatment in humans, Natl. Cancer Inst. 89,718-724, (1997).
  24. Waikar M. V., Hegde S. S., Ford A. P. D. W., Clarke D. E.: Pharmacological analyses of endo-6-methoxy-8-methyl-8-azabicyc1o[3.2.1]oct-3-yl-2,3-dihydro-2-oxo-1H- benzirnidazole- l-carboxylate hydrochloride (DAU 6285) at the 5-hydroxytryptamine4 receptor in the tunica muscularis mucosae of rat esophagus and ileum of guinea pig: role of endogenous 5-hydroxytryptamine, J. Pharmacol. Exp. Ther., 264, 654, (1993).
  25. Lawton C. L., Blundell J. E.: 5-HT and carbohydrate suppression: effects of 5-HT antagonists on the action of D-fenfluramine and DOI, Pharmacol. Biochem. Behav., 46, 349, (1993).
  26. Langle U. W., Wolf A., Cordier A.: Enhancement of SDZ ICT 322-induced cataracts and skin changes in rats following vitamin E- and selenium-deticient diet, Arch. Toxicol., 71,283, (1997).
  27. Kandasamy S. B.: Effect of Ondansetron and ICS 205-930 on Radiation-Induced Hypothermia in Rats, Radiat. Res., 147, 741, (1997).
  28. Gupta S. S., Sharma S., Narula A.K: Heterocarboxylates of an unsymmetrical diorganotin(IV)dichlorate, J. Chem. Res., 11,406, (1994).
  29. Morzyk-Ociepa B., Rozycka-Sokolowska E.: Structures and spectroscopic studies of indolecarboxylic acids. Part III. Diamminetetrakis-μ-(O,O'-indole-3-carboxylate) dicopper(II), J. Mol. Struc, 784, 69-77, (2006).
  30. Romanelli M. N., Ghelardini C, Dei S., Matucci R., Mori F., Scapecchi S., Teodori E., Bartolini A., Gaili A., Giotti A., Gualtieri F.: Synthesis and biological activity of a series of aryl tropanyl esters and amides chemically related to 1H-indole-3-carboxylic acid endo 8-methyl-8-azabicyclo[3.2.1.]oct-3-yl ester: development of a 5-HT4 agonist endowed with potent antinociceptive activity, Arzneim.-Forsch., 42, 913, (1993).
  31. Karle I. L., Britts K, Gum P.: Crystal and molecular structure of 3-indolylacetic acid, Acta Cryst. 17,496, (1964)
  32. Endo S., Itoh M, Serizawa O., Serotonergic regulation of the spinal cord content of thyrotropin releasing hormone in the cerebellar ataxia mutant mouse, J. Neurol. Sci., 118, 194, (1993).
  33. Jiang J. C., Gietzen D. W.: Anorectic response to amino acid imbalance: a selective serotonin 3 effect?, Pharmacol. Biochem. Behav., 47, 59, (1994).
  34. Contesse V., Hamel C., Delarue C., Lefebvre H., Vaudry H.: Effect of a series of 5-HT4 receptor agonists and antagonists steroid secretion by the adrenal gland in vitro, EUL J. Pharmacol., 265, 27, (1994).
  35. Huang Y. L., Chen C. C., Hsu F. L., Chen C. F.: A new lignan from Phyllanthus virgatus, J. Nat. Prod., 59, 520, (1996).
  36. Morzyk-Ociepa B., Rozycka-Sokolowska E.: X-ray and infrared spectrum on metal complexes with indolecarboxylic acids. Part V. Catena-poly[{aqua(h2-indole-3¬propionato-O,O0)zinc} -h2-:-m-indole-3-propionato-O,O0:-O], Vib. Spectrosc, 43, 405¬-414, (2007).
  37. Pattnaik S. K Chand P. K: Rapid clonal propagation of three mulberries, Morus cathayana Hemsl., M. lhou Koiz. and M. serrata Roxb., through in vitro culture of apical shoot buds and nodal explants from mature trees, Plant Cell Rep., 16, 503, (1997).
  38. Gartz J.: Variation der Indolalkaloide von Psilocybe cubensis durch unterschiedliche Kultivierungsbedingungen, Beitraege z. Kenntnis d. Pilze Mitteleuropas, 3, 275, (1987).
  39. Hart H., Craine L.E., Hart D. J.: Chemia organiczna, PZWL, Warszawa (1999) 329.
  40. Appel J. B., West W.B., Buggy J.: LSD, 5-HT (serotonin), and the evolution of a behavioral assay, Neurosci. Biobehav. Rev., 27, 693-701, (2004).
  41. Kaneez F. S., Arshad S. S.: The metabolism of serotonin in neuronal cells in culture and platelets, Exp. Brain Res., 183,411-416, (2007).
  42. Stöcking J., Zenk H.: Isovincoside (strictosidine), the key intermediate in the enzymatic formation of indole alkaliods, Febs Lett., 79, 233-237, (1977).
  43. Rinaldi A.C.: Meeting report - Copper research at the top, BioMetals, 13, 9-13, (2000).
  44. Takeda A.: Zinc homeostasis and functions of zinc in the brain, BioMetals, 14, 343¬-351, (2001).
  45. Zhou Q., Hambley T. W., Kennedy B. J., Lay P. A., Turner P., Warwick B., Biffin J. R., Regtop H. L.: Syntheses and Characterization of Anti-inflammatory Dinuclear and Mononuc1ear Zinc Indomethacin Complexes. Crystal Structures of [Zn2(Indomethacin)4(L)2] (L = N,N-Dimethylacetamide, Pyridine,I-Methyl-2-pyrrolidinone) and [Zn(Indomethacin)2 (LI)2] (LI = Ethanol, Methanoi), Inorg. Chem. 39, 3742, (1999).
  46. Weder J. E., Dillon C. T., Hambley T. W., Kennedy B. J., Lay P. A., Biffin J. R., Regtop H. L., Davies N. M.: Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized, Coord. Chem. Rev., 232, 95-126, (2002).
  47. Morzyk-Ociepa B., Marciniak B.: X-ray and vibrational spectra on metal complexes with indolecarboxylic acids: Part IV. Catena-poly[ {aqua(ή2 -indole-3-carboxylato¬O,O')zinc }-μ-indole-3-carboxylato-O:O'], Vib. Spectrosc, 43, 297-305, (2007).
Cytowane przez
Udostępnij na Facebooku Udostępnij na Twitterze Udostępnij na Google+ Udostępnij na Pinterest Udostępnij na LinkedIn Wyślij znajomemu